Capital in the 21 Centurey Essay Example | Topics and Well Written Essays - 750 words

Capital in the 21 Centurey - Essay Example Bonds were, in essence, one population’s claim over the rest who paid they’re taxes. However, to find out the wealth’s ownership has been much complex as it is today in a world characterized by what Piketty refers to as â€Å"financial intermediation†. The existing financial system with the banks makes it complex to realize the ownership of wealth which is deposited by the common man and invested by the bank. Businesses then operated in similar ways as the present times with entrepreneurs founding startups and then offering stock options, earning capital gains, and investing some of it back into the business. The bottom line is that capital was an essential part of the society, beyond narrative stories, some of which operated as dynamic assets. By comparing the early businessman with the present system, the author has drawn many parallels in both the systems of capital and investment. With this Piketty (83) points out the risky nature of capital that has always been so at least in its early stages when it is also entrepreneurial in nature. The modern perception has it that capital has become more dynamic ever since the eighteenth century. The recorded literature from Britain and France provide the most information. It is observed that the capital-income ratio has remained stable between the eighteenth and nineteenth centuries for both Britain and France following a similar trend. This was followed by a sudden surge in the twentieth century which then returned to similar levels during the World War I (Picketty, 86). Hence, national capital which is the sum of private and public capital was defined as the sum of farmland, housing, other domestic capital, and net foreign capital (Piketty, 87). Foreign capital was extensively shaped by regional colonial powers and the variable played an important role in determining national capital. The most prominent changes have been the replacement of farmland while total capital

The impact on business continuity from the failure of outside Essay

The impact on business continuity from the failure of outside utilities - Essay Example When Hurricane Sandy swept across New York City shut down many businesses, Goldman Sachs is one business which managed to mitigate and protect itself from the adverse impact of the disaster. When it was apparent New York City would not be spared of the hurricane menace, the business owner stacked bags around its head offices (The Economist). By the time storm was settling, Goldman Sachs’ headquarters was one of the few offices that remained safe, dry and with proper illumination in the downtown Manhattan area. Even as firms such as Goldman Sachs prepared themselves to counter the disaster, a block away was a completely disrupted and flooded headquarters of Verizon with all its services interrupted. Verizon had its phone and internet cables all submerged, cutting off millions of services of the company. However, the firm managed to reroute most of its traffic through their other networks. ConEdison, an electricity utility company which serves the city of New York had nearly a million of its customers with no electricity when their underground equipment and power lines destroyed. Although the company had designed its facilities to sustain up to 3.8 meters of any tidal surge, the Hurricane Sandy surpassed this and hit 4.3 meters (The Economist). This interruption went for more than nine days, causing massive losses to businesses and individuals homes that relied on their services. Hurricane Sandy is one of the disastrous events that clearly tested various firms’ ability to cope with unexpected disasters.

Early childhood education Essay Example for Free

Early childhood education Essay Early childhood education has for a very long time been neglected by educational planners in Australia. Early childhood education is one of the most important stages in pursuit of education given the fact that the foundation children receive in their pre-school years and in early school years goes along way in shaping their prospect careers. Early childhood education in Australia is faced with several challenges key of which include lack of a systematized curriculum covering both private and public sectors. The other challenge is lack of enough trained teachers in early childhood education which has seen the standards of early childhood education deteriorate in the recent past. Although the Ministry of Education in Australia has on several occasions initiated commissions to offer long lasting solutions to the challenges highlighted above, none of this has to date yielded into success. Failure for recommendations contained in various commissions set up by the Howard government can be attributed to lack of clear policy governing early childhood education provision in Australia. Early childhood education provision in Australia has traditionally been teacher-centered as opposed to being child-centered. It has lacked impetus in that instead of focusing on the needs of the children the kind of education provided in early stages of schooling has lacked in objectivity. There is therefore a need for a lot more emphasis on children interest from an early age so as to overcome some of the challenges witnessed in latter stages of education such as upper primary and secondary levels. If children are given enough orientation at the pre-school and early school levels such children are likely to grow up with a clear focus on areas of interest something which can help resolve the low literacy and accounting skills evident amongst high school and primary schools students. Teacher training will play a very significant role in accomplishing the goals of early childhood education. Teachers play a critical role in curriculum interpretation and unless the teachers are able to interpret curriculum effectively efforts to streamline early childhood education in Australia are likely to fail. To counter such challenges there is a need for the government to offer incentives to early childhood education teachers for instance offering free training programs or alternatively offering government sponsored training programs (MacNaughton, Williams, 1998). There lacks proper curriculum to guide early childhood education and the one in place has been in use for many decades something which clearly indicates that it could have outlived its use (Margetts, 2003). Until stakeholders in early childhood education come up with solutions as well as recommendations geared towards streamlining early childhood education to meet modern educational needs then all efforts geared towards achievement of effective early childhood education provision in Australia are likely to be unsuccessful. In conclusion, early childhood education in Australia is in deplorable state. There is a need for the government to include in its educational agenda, policies which will see more funding directed to early childhood education. The government must take initiative and implement the necessary amendments to the education act which has not served early childhood education properly. There is a need for integration of early childhood education to primary education and secondary education for purposes of achieving transition so that early childhood education is not viewed as a stand alone sector in education. References MacNaughton, G. Williams, G. (1998. 69-79) Techniques for Teaching Young Children: Choices in theory and practice, Addison Wesley Longman Australia Pty Ltd, Frenchs Forest, NSW. Margetts, K. (2003. pp. 45-65) Child care arrangements, personal, family and school influences on childrens adjustment to the first year of schooling, Proceedings of the Australian Early Childhood Association Biennial Conference, Hobart 10–13 July 2003, Australian Early Childhood Association.

Roles of MicroRNAs in the Cell Cycle

Roles of MicroRNAs in the Cell Cycle Evaluate the roles of microRNAs in the cell cycle and explain the consequences of disruption to microRNA activity in named diseases Introduction The presence and activity of various proteins are required in the cell cycle progression.(1) The regulation of these protein levels is vital for the understanding of the cell cycle control and its dysregulation. The dysregulation results genetic mutation related diseases. For instance, overexpression of cyclins or the elimination of CDK inhibitors or pRB due to genetic mutation are common cause in human cancer.(2) Therefore, the proper control of protein levels is crucial for the cell cycle. MicroRNAs are ~22-25 nucleotide non-coding RNAs.(3) It is post- transcriptional repressor of mRNA; control the stability and translation of protein-coding mRNAs. (1, 3). MiRNAs bind the 3’ untranslated region (3’UTR) of target mRNAs. The binding of miRNA- protein complexes to mRNA causes translation inhibition or destabilisation of target transcripts.(1) This is resulting in the downregulation of the protein encoded by mRNA. Figure 1 : microRNA as post-transcription inhibitor in protein encoding (4) MicroRNAs control the levels of numerous cell cycle regulators that controls cell proliferation.(1) The alternation of protein levels of critical oncogenes or tumour suppressor genes, which causes by miRNAs deregulation may also lead to proliferative diseases such as cancer. MiRNAs that linked to human cancers, known as â€Å"oncomirs†. These are divided into two group, those miRNAs that are upregulated in cancer which are likely to be acting as oncogenes and those downregulated in cancer which are likely to be acting as tumour suppressors.(5) Approximately 30-60 % of the human genome, regulated by miRNAs. As a consequence, any modulations of the target transcript expression, miRNAs can affect various signalling pathways and cellular process such as apoptosis, proliferation or differentiation. Therefore, miRNAs could consider as cancer targets. Besides cancer, some miRNAs genes cause or contribute in many inherited and genetic based diseases. For instance, miR-26b upregulated in Alzerimer’s disease, (6) miR 96 causes nonsyndromic progressive hearing loss (7) and miR -184 causes Familial Keratoconus with Cataract.(8) Nevertheless, some miRNAs’ genes are beneficial; display antiproliferative properties.(1) For example, the down-regulation of miR15s and miR – 16 – 1 in chronic lymphocytic leukaemia, prostate cancer and pituitary tumours, leading to the inhibition of tumour growth and induce cell cycle arrest at the G1 ­ phase by target cell cycle regulators ( cyclin D1, cyclin E1, cyclin D3 and CDK6). (9) As miRNAs proposed to control the expression up to one third of all genes and possibly utilised as diagnostic and prognostic marker for many genetic based diseases.(10) Therefore, it is important to evaluate its role in the cell cycle and its dysregulation. The different roles of MicroRNAs in the cell cycle The understanding of miRNA has increased over the past 10 years, and particularly the involvement of miRNAs in cancer. Nowadays, cancer is a common disease, which occurs to one third of the population. There are lots of cancer treatments available, however to identify an effective treatment is still challenging.(9) Therefore, it is important to develop a new treatments with less side effect are greatly demanded. A greater understanding of miRNA could possibly lead to better diagnostic and treatment of cancer.(9) Let-7 Let-7 has an essential role in cell cycle and the differentiation of cell cycle terminals. Let-7 is coded by 12 genes; these are produced from the eight genomic loci. These 12 genes are located at a region, which is frequently deleted in cancer. Throughout the lung cancer examination, it has been showed that a low level of let-7 relates to the poor prognosis. The expression of let-7 induces the suppression growth of cell and human tumour cell lines.(12) Over-expression of let-7 in lung cancer causes the lowered cell division and stopped the progression of cell cycle. Ras, Caspase-3 and HMGA2 genes are targeted by let-7 for controlling tumour growth. Furthermore, let-7 represses number of cell cycle regulator gene: cyclin D1, cyclin A, cyclin D3, CDK4 and CCNA2, CDK6, CDC25A and CDK8. (13) MiR-15a/16 Chromosome 13q14 region is frequently deleted in more than 50% of the B-cell chronic lymphocytic leukaemia (CLL). This region of the chromosome includes the expression of miR-15a/16 cluster. Further studies have identified that miR-15a/16 is located at the 30 kb region of the loss chromosome in CLL. (14) In CCL patients, about 70% of the patients have miR-15a and miR-16 either deleted or down regulated; same applies to gastric cancer and pituitary adenomas cell lines. The miR-15a and miR-16 target cell cycle regulators such as cyclin D1, cyclin D3, cyclin E1 and CDK6, this causes the cell cycle arrest during the G1 phase.(13) miR-15 and miR-16 in colon cancer cell lines presented with a high level of down-regulated transcripts for gene related to cell-cycle progression. Moreover, the high expression of miR16 which leads to increase G0 and G2 phase accumulation through down-regulating the gene expression of cell cycle, CARD10, CDK6 and CDC27. These evidenced the miR15a and miR16 associated with complex gene expression.(12) Figure 2: Cell cycle and proteins that are involved in the cycle. (11) MiR-17/20 The miR-17/20 induces suppression of tumour growth in the breast cancer and human B-cell line; it encodes 6 mature miRs in a 1 kb region. MiR-17/20 target several cell cycle regulators, including E2F, Rb, c-myc and cyclin D1, for the time control of cell cycle. At G1 phase (figure 2) , Cyclin D1 and c-myc are induced and inactivation of E2F1 when bind to Rb. The transition of G1 to S phase of the cell cycle requires the miR-17/20 cluster.(13) The miR-17 family might involve in inhibit or promote cellular proliferation. In a low level of mitogenic stimulation, miR-17 possible involves in the E2F signalling maintenance to be at a level below threshold for proliferation. Furthermore, the missing miR-17-19 cluster has been identified in many malignancies, and disruption of miR-17 expression possible reduces the proliferation of certain breast cancer cell lines. The suppression of irregularly high E2F activation, the apoptosis response might be eliminated by the miR-17-92 cluste r, then this function as an oncogene. Subsequently, in various solid and haematopoietic malignancies are found to have amplificated and over-expressed miR-17 family. These have indicated that miR-17/20 play a essential role in cellular proliferation and progression of malignancies. (12) MiR-221/222 The regulation of cell cycle by miR-221/222, which it targets the CDK inhibitors. The miR-221 and miR-222 ectopic expression initiate CDK2, aiding the transition of G1 to S phase of cell cycle and p27kip2 and p57kip2 are negatively regulated which lead to increase tumour growth. This is frequently identified in human breast cancer tissues.(13) In addition, miR-221 and miR-222 act as a direct regulator of p27. The over-expression of this cluster increases cellular proliferation and allowed anchorage growth independently. The suppression of miR221 and miR-222 initiated G1 phase arrest in breast cancer cell lines. It is found that miR-221/222 is over-expressed in several human tumors. (12) Table 1: miRNA genes and clusters that target cell cycle regulators and its deregulation in cancer. (1) MiRNA related diseases Chronic Lymphocytic Leukaemia Chronic Lymphocytic Leukaemia (CLL) occurs due to the homozygous or heterozygous deletion of the chromosomal region 13q14.3. MiR – 15a and miR -16-1 are located in this region as shown in Calin et al’s study.(9, 15) This provided evidence that miRNAs might be involved in the pathogenesis of CLL and other human cancers.(9) These genes were found to be deleted in 68 % of CLL patients.(15) MiR-15a and miR-16-1 leads to the inhibition of tumour growth by negatively regulate BCL2; anti-apoptotic gene.(9) They also induce cell cycle arrest at the G1 phase by targeting cell cycle regulators ; cyclin D1, cycline D3, cyline E1 abd CDK6.(9) The deletion of miR-15a and miR-16-1 associated with CLL patients’ phenotypes; the loss of these two genes accelerates B- lymphocytes proliferation by modulating genes’ expression controlling cell-cycle progression.(9) As consequences, CLL clinical features occurs. Breast cancer breast cancer is oestrogen hormone dependant disease. Breast cancer occurs when the number of oestrogen receptors (ER) increase abnormally. Alb1 genes are oncogenes in breast cancer. It enhances the transcriptional activity of the ER and E2F1 and other transcription factors. (16) Alb1 is a rate-limiting factor for oestrogen. (16) E2F1 is involving in growth hormone–signalling pathway and mediated breast cancer cells growth. (16) From the Hossain et al’s study, mir-17-5p play a role of tumour suppressor, which controls the cell proliferation of breast cancer cells. (16) In cell culture experiment, AlB1 expression was downregulated by mir-17-5p through translational inhibition. This resulted in decreased ER and cancer cells’proliferation. As mir-17-5p binds to the cyclin D1 3’UTR in the MCF-7 breast cancer cells . It inhibits cyclin D1 expression, resulting in suppressed cell proliferation and cell cycle arrest.(9) Conclusion MicroRNAs are crucial in the cell cycle. The Mitchell et al’s study has shown that miRNAs displayed high stability in tissue from human plasma. (17) It is possible that miRNA might be useful biomarker to indicate disease state. Moreover, the demonstration of miRNA profiles are potential for distinguishing a development of tumour’s origin and miRNA that acts like tumour suppressor in cancer.(18) From Lu et al’s study, they have demonstrated that there are lower miRNA expression in poorly differentiated as compared to highly differentiate tumour; which is very interesting fact and provide evidence to shoe that possibility that miRNA could utilised in disease diagnostics. (19) Therefore, further researches should carry out to gain more understandings and invent more effective treatment. References 1. Bueno J, Marà ­a., Malumbres M. MicroRNAs and the cell cycle. 2011;1812(5):592–601. 2. Malumbres M, Barbacid M. To cycle or not to cycle: a critical decision in cancer. Nat Rev Cancer. 2001;1(3):222-31. 3. Carleton MC, A., Michele. Linsley,S.,Peter. MicroRNAs and Cell Cycle Regulation. Cell cycle. 2007 September 1;6(17):2127-32. 4. The image of microRNA [image on the internet]. 2013 [cited 2014 February 4]. Available from : http://www.fireflybio.com/introduction_to_microRNA. 5. Johnson CD, Esquela-Kerscher A, Stefani G, Byrom M, Kelnar K, Ovcharenko D, et al. The let-7 microRNA represses cell proliferation pathways in human cells. Cancer Res. 2007;67(16):7713-22. 6. Absalon S, Kochanek DM, Raghavan V, Krichevsky AM. MiR-26b, upregulated in Alzheimers disease, activates cell cycle entry, tau-phosphorylation, and apoptosis in postmitotic neurons. J Neurosci. 2013;33(37):14645-59. 7. Mencà ­a à ea. Mutations in the seed region of human miR-96 are responsible for nonsyndromic progressive hearing loss. Nature Genetics. 2009;41(5):609-13. 8. Hughes AE, Bradley DT, Campbell M, Lechner J, Dash DP, Simpson DA, et al. Mutation Altering the miR-184 Seed Region Causes Familial Keratoconus with Cataract. The American Journal of Human Genetics. 2011;89(5):628-33. 9. MicroRNA in Cancer: Spinger Science and Business Media Dordrecht; 2013 [cited 2014 February 2]. Available from: http://books.google.co.uk/books/about/MicroRNA_in_Cancer.html?id=RS8qLrSkdkgC. 10.Yang MM, Joerg. Discovery, biology and therapeutic potential of RNA interference, microRNA and antagomirs. 2008;117(1):94–104. 11. Cohen B. The image of cell cycle [image on the internet]. 2013 [cited 2014 February 4]. Available from : http://www.studyblue.com/notes/note/n/neoplasia-vii-cancer-critical-genes-and-familial-cancer-syndromes/deck/6316935. 12. Chivukula R, Raghu. Mendell,T., Joshua. Circular reasoning: microRNAs and cell-cycle control. October 2008;33(10):474-81. 13. Yu Z, Baserga R, Chen L, Wang C, Lisanti MP, Pestell RG. microRNA, Cell Cycle, and Human Breast Cancer. American Journal of Pathology, The. 2010;176(3):1058-64. 14. Cho WC. OncomiRs: the discovery and progress of microRNAs in cancers. Molecular Cancer [Internet]. 2007 2007-09-25 [cited 2014 Febuary 5]; 6(1):[60 p.]. Available from: http://www.molecular-cancer.com/content/6/1/60. 15. Calin GA, Dumitru CD, Shimizu M, Bichi R, Zupo S, Noch E, et al. Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. 2002;99(24). 16. Hossain A, Kuo MT, Saunders GF. Mir-17-5p Regulates Breast Cancer Cell Proliferation by Inhibiting Translation of AIB1 mRNA. Molecular and Cellular Biology. Novemble 2006;26(20). 17. Mitchell PS, Parkin RK, Kroh EM, Fritz BR, Wyman SK, Pogosova-Agadjanyan EL, et al. Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci U S A. 2008;105(30):10513-8. 18. Hydbring PV-B, Gayane. Clinical applications of microRNAs F1000Research. 2014. 19. Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D, et al. MicroRNA expression profiles classify human cancers. Nature. 2005;435(7043):834-8.

My Personal Strengths and Weaknesses Essay -- Personal Narrative Essays

  Ã‚  Ã‚  Ã‚  Ã‚  I believe that life is a learning experience and being able to recognize our own strengths and weaknesses can help us become better individuals in anything we choose to do, whether it is positive abilities and skills that can help achieve our goals or negative personal areas that need improvement. Knowing yourself and what you can do, can help you recognize and overcome your weaknesses.   Ã‚  Ã‚  Ã‚  Ã‚  One of my greatest strengths at work that I have recognized would have to be my ability to be a well-organized individual. I tend to write what I have to do down on paper and prioritize what is more important to least important. In doing this, it helps me organize and accomplish my work and meet deadlines that are important. A personal strength that I have at home is patience. I am a mother of a beautiful three year old little girl who is a handful. Patience is my greatest strength as a parent and individual which I possess especially being a single mother. I am a dedicated and hard working mother and I always make sure that my daughter gets the love and attention she needs.   Ã‚  Ã‚  Ã‚  Ã‚  In my Learning team, my personal strength is having good people skills. I meet and get involved with new people everyday whether it be work or school related. I enjoy speaking, listening and giving input to my team members so that they are aware that they can count on me to participate as a team player in our Learning Team. Good people skills are very important in a group setting because of all the di... My Personal Strengths and Weaknesses Essay -- Personal Narrative Essays   Ã‚  Ã‚  Ã‚  Ã‚  I believe that life is a learning experience and being able to recognize our own strengths and weaknesses can help us become better individuals in anything we choose to do, whether it is positive abilities and skills that can help achieve our goals or negative personal areas that need improvement. Knowing yourself and what you can do, can help you recognize and overcome your weaknesses.   Ã‚  Ã‚  Ã‚  Ã‚  One of my greatest strengths at work that I have recognized would have to be my ability to be a well-organized individual. I tend to write what I have to do down on paper and prioritize what is more important to least important. In doing this, it helps me organize and accomplish my work and meet deadlines that are important. A personal strength that I have at home is patience. I am a mother of a beautiful three year old little girl who is a handful. Patience is my greatest strength as a parent and individual which I possess especially being a single mother. I am a dedicated and hard working mother and I always make sure that my daughter gets the love and attention she needs.   Ã‚  Ã‚  Ã‚  Ã‚  In my Learning team, my personal strength is having good people skills. I meet and get involved with new people everyday whether it be work or school related. I enjoy speaking, listening and giving input to my team members so that they are aware that they can count on me to participate as a team player in our Learning Team. Good people skills are very important in a group setting because of all the di...

Opium and Dreams in the Romantic Period Essay -- essays research paper

During what is generally defined as the Romantic period, many poets, scientists and philosophers were greatly intrigued by dreams. Southey kept a dream journal, as did Sir Hymphry Davy, a close friend of Coleridge’s; Thomas Beddoes wrote of dreams from a medical perspective in Hygeia and dreams were often a hot topic of conversation at the dinner parties of those who kept company with poets and the like (Ford 1998:5). There were many contradictory theories on the importance, interpretation and origin of dreams, at this time. Some believed that dreams were a form of divine inspiration, others that they were caused by spirits that temporarily possessed the body of the sleeper, while there were those who thought that dreams were a manifestation of the body’s physical condition. De Quincey and Coleridge were two writers who both held an exceptional interest in dreams, each with their own ideas on the subject. In this essay I propose to examine De Quincey’s and Coleri dge’s ideas on dream and daydream, and to show that opium was a profoundly influencing factor in their lives, works and dreams. I shall start by briefly outlining some of De Quincey’s and then Coleridge’s ideas on dreams; I shall then move on to ask what was the effect of opium on their creativity, dreams and imagination, before looking at how dream and daydream are distinguished in their ideas. Finally I wish to include a brief section on the anticipation of Freud, and to close with the question of how important opium was to the writing of my chosen authors. Since dreams and opium are so intertwined in both Coleridge and De Quincey I feel it is appropriate to consider the two subjects alongside each other.   Ã‚  Ã‚  Ã‚  Ã‚  In Thomas De Quincey’s Confessions of an English Opium-Eater, dreams and opium are considered simultaneously because he records the largest effect of his opium-eating to have been on his dreams. He first became aware of the effects by a re-awakening of a faculty generally found in childhood: I know not whether my reader is aware that many children, perhaps most, have a power of painting, as it were, upon the darkness, all sorts of phantoms; in some, that power is simply a mechanic affection of the eye; others have a voluntary, or a semi-voluntary power to dismiss or summon them†¦In the middle of 1817, I think it was, that this faculty became positively distressing to... ...a fashion that had started long before; and there has only ever been written the one Kubla Khan.   Ã‚  Ã‚  Ã‚  Ã‚  De Quincey wrote that men are ‘disguised in sobriety’, so opium and dreams serve to expose the true mind of man and perhaps the unconscious mind. Whatever the effect of opium on Coleridge and De Quincey; on their philosophies, on their dreams and on their lives; one cannot truly know the depth or extent of it, but to take opium and go through the experience personally. It is certainly undeniable that it was an influence and an extremely important one that continues beyond the present: furthering the exposure of mans’ psychology through the portal of dreams. Bibliography Coleridge, S. T., Poems, Everyman’s Library, London, 1999. Coleridge, S. T., Biographia Literaria, William Pickering, London, 1847. De Quincey, T., Confessions of an English Opium-Eater and Other Writings, Oxford World’s Classics, Oxford, 1996. Ford, J., Coleridge on Dreaming, Cambridge University Press, Cambridge, 1998. Hayter, A., Opium and the Romantic Imagination, Faber and Faber, London, 1968. Marcus, T., Opium in Literature and London, Issue 3. Zembla Magazine, London, 2004.

Mcdonaldization and bureaucracy

With the changing state of the society, the concepts of Mcdonaldization and bureaucracy continue to become fundamental. The question of the rationality in their application within the organizations however remains a point of debate. Bureaucracy can be defined as the structural concept and the nature of regulations which are put to provide a control measure into the activities of organization or even the government structures. Their basic comes inform of standard procedure, various structures in the formulating or undertaking responsibilities, the nature of hierarchies within such of organization above the set of the personal relationship within such organizations. This is a sociological concept that seeks to define the inputs of the administration within these organizations in executing their roles and the impacts of enforcing the various rules. An authentic definition of bureaucracy is however to take the form of four structures. These are labor division by the administration, an adequate system of personnel, a layout of organization hierarchy and the network system connecting the organization activities Mcdonaldization is a work defining formula whose root schedule lies in three principles. Control, uniformity and efficiency. Across the globe, the two concepts are however deeply used in organization. In the context of their application, a rational sociologist is left to wonder the logics behind their rationality. At one place, we can argue of the positive implication in the application of the two principles. On the other hand, we can argue of the same as compromising humanity. Due to the diversity in the understanding of these principles, the argumentation in this paper will be basically limited to the benefits of their structures. At the work place is a set of activities, structures, processes and personnel’s for performing different activities. A solid subject of these entire variables brings up the organizational behaviour. Consequently, the aspect of organizational behaviour plays an intrinsic role in formulating the nature of achievement of the organizations goals. For an adequate functional therapy of the workers in performance of their roles, the management should formulate some specific motivational parameters. However, motivation is synonymous to the nature of management. Through adequate tool of management, the employees are subject to motivation. However, poor management structure is harmful to the good of the organization’s workers. (Peters, 2001, p. 79) The above two concepts provide a package of motivational incentives to the workers. From one point of the argument, they can be described as benchmarks for a promoted interpersonal relationship between the workers.   Upright organizational behaviour is the chief contributor towards the success of the organization. Their provision gives an incentive into the interpersonal phenomena between the workers. For both of them, their applications provide efficiency in the workers performance of their activities. Efficiency is the most fundamental basics for ensuring optimality and economical application into the organizations activity.   With optimal characteristics, the organization gets its activities done in the most economical manner in the lowest cost level to yield the greatest benefits. Efficiency safeguards the organizations process into threats of poor performance. With this virtue, the aim of achieving the organizations goals and objectives is never ridiculous but falls within frontiers of success. In its nature, it will involve the perpetuation of the variable of control. The diversity of the organizations activities requires an outlay of control. Control is where the activities and process are subject to be monitored so that their execution compliments the basic laid down requirements and within the framework of the institution structures. The exercise of the concepts provided a solid impression for promoting control in the activities and process within the organizations. With the positive organizational behaviour, the structures within the organization are safeguarded. Every activity by the workers gives an impression of a  Ã‚   positive interpersonal-hood, cohesiveness and harmony between them and the structures. In exercise of the control principle within the organization, the two methods of managerial leadership help to ensure the control/monitor the interpersonal differences that may exist between the different persons. Sound organizational behaviour is important for every aspect of communication. As a rule, communication plays a remarkably important role in the performance of the organizations activities. In the nature of the transactional outlay involved at the work place, a passive or active system of communication should never be compromised. (Peters, 2001, p. 84) With the controlled nature into the activities of the organization, this is the foremost launching pad for its success in terms of achieving its goals and objectives. Consequently McDonaldization and bureaucracy show the nature of the organizational leadership parameters. Since the organization is endowned by a subject of goals and objectives with the aspects of minimal resource packages, a good model of leadership is basic for providing their achievement. As the model of such leadership continues in been intensified, the characteristic hood of the above two forms logical framework for the involved success into the organization. Both the two systems are methods providing a support for some positive regard to the organization structure.   They stress on solid methods that provide a support for an adequate system of governance. They both provide a basic imagery into the guiding factors that seek to enhance a structural framework in the association and relationship between person, activities and processes. This is the first attribute towards providing understanding and agreement between such organizational blocks before minimizing conflict. The essence and subject of conflict can be said to be the biggest threat and enemy to the  Ã‚   organization. This is however a subject result of the conflict theory which acts to provide an interactive manner between the persons and structures in the organization. With the various roles and diversity in the activities and elements in the organization, the above two principle comes as a remedy to the possible consequences of conflict. Though a well-structured system of activity by the parties into this organization, conflict is evaluated and done with. This is an important tool towards achieving the goals and objectives of the organization. As a conclusion therefore, the concepts of bureaucracy and MacDonaldization comes as a remedy into the weaknesses of an organization. Through the application of these concepts, the organization character/nature is brought out as radically of a positive image into the success factor. At one level, the concepts seek to provide harmony and cohesiveness into the different persons within the organization, with an adequate layout of the process, roles and activities, and the persons to perform them, the internal environment is given an impression of promoted activity. Either, they aim at providing an adequate support into the optimal allocation of resources. This is through the adequate and planned nature of the organization. Both of the concepts are important in providing a solid support into the organizational activity. Work cited Peter, B. The politics of Bureaucracy, London: Routledge, 2001